Moreover, in TCGA breast tumors, the predicted E2F1 transcription factor activity, inferred from the tumor sample’s protein expression profile using a trained affinity regression model [28, 29], positively correlates with CENPI mRNA level in the tumors (r=0.5186, p<0.0001, Spearman correlation; Figure 3E). This evidence concerns the gene E2F1 and breast neoplasm.