Fourth, when we adjust the CENPI expression levels in ER+ breast cancer patients for cell proliferation by dividing these levels by the respective KI67 levels, patients with CENPI/KI67 levels above the median have a significantly poorer prognosis than those with CENPI/KI67 levels below the median (p=0.0050, log-rank test) (Figure 4B). This evidence concerns the gene MKI67 and breast cancer.