Based on these data and on the postulated function of H3K27 methylation in transcription repression, we reasoned that protection of H3K27me2/3 modification by inhibition of corresponding demethylases should repress AR-driven transcription in PCa and CRPC, thus providing a new potential options for PCa treatment (the model in Figure 7). Here, MBD2 is linked to posterior cortical atrophy.