In the current meta-analysis, we observed a significant association between the LEPR Gln223Arg gene polymorphism and T2DM in the Chinese population under the allele (OR: 1.432), dominant (OR: 1.466), recessive (OR: 0.539), heterozygous (OR: 0.700), and homozygous (OR: 0.472) genetic models. This evidence concerns the gene LEPR and type 2 diabetes mellitus.