SETD2 and breast cancer: In addition to SETD2, a review of relevant literature identified a further three candidate telomerase repressor genes that (i) are located proximal to or within the 3p21.3-p22 region, (ii) have been previously implicated in breast cancer and (iii) have been shown to play a functional role in the epigenetic regulation of target gene transcription through chromatin remodelling and/or have been implicated in hTERT regulation within other cancer cell types.