PBRM1 and breast cancer: In order to carry out a preliminary analysis of the putative tumour suppressive role of SETD2, BAP1, PBRM1 and PARP-3 within breast cancer cells, we carried out gene CNV analysis of all candidates within a panel of nine breast cancer cell lines relative to three normal HMEC cell strains (see Supplementary Table 1 for the origin of each cell line/strain used).