Moreover, this immunophenotypic signature identified even almost all neutropenic patients (37 out of 41, 90.2%; χ2 = 49.5, P < 0.0001; Figure 3A), also including those 4 cases CD8+ T-LGL leukemia with neutropenia that had wild type STAT3. In more detail, among the 41 patients with CD16+/CD56- immunophenotype, 33 were both mutated and neutropenic, 4 were STAT3 mutated without neutropenia and other 4 were neutropenic with wild type STAT3. Here, CD8A is linked to leukemia.