As indicated, CD16+/CD56- subgroup showed the ANC value significantly lower than that observed in the remaining CD8+ groups and CD4+ T-LGL leukemia patients (mean ANC ± SEM: 795.46 ± 80.03 mm3, 2,855.11 ± 224.54 mm3; 2,635.76 ± 193.81 mm3, respectively, P < 0.05; Figure 3B). The gene discussed is CD8A; the disease is T-cell large granular lymphocyte leukemia.