CD4 and T-cell large granular lymphocyte leukemia: By Real-Time PCR, we observed that Fas ligand transcriptional expression median level was higher in CD16+/CD56- CD8+ T-LGL leukemia patients as compared with the non-neutropenic patients belonging to the other immunophenotypes, both CD8+ T-LGL leukemia and CD4+ T-LGL leukemia (7.66 ± 0.87, 2.45 ± 0.22 and 2.35 ± 0.28 arbitrary units, respectively; P < 0.001; Figure 5A).