CD4 and T-cell large granular lymphocyte leukemia: By flow analysis, we observed that 68 out of 101 patients (67.3%) were characterized by classical CD3+/CD8+/CD4- expression (CD8+ T-LGL leukemia), while the remaining 33 patients (32.7%) were distributed among CD3+/CD4+/CD8+dim (n = 23, 22.8%) and CD3+/CD4+/CD8- (n = 10, 9.9%) phenotypes.