rs7897156C>T is located at the 5′ untranslated region of BUB3 and can change the promoter activity of BUB3. We investigated the effect of rs7897156C>T on the promoter activity of BUB3 using a luciferase assay in the H1299 and A549 NSCLC cell lines. The gene discussed is BUB3; the disease is non-small cell lung carcinoma.