For rs737008 in PRM1 and rs1646022 in PRM2, we found a protective effect for male infertility in several combined genotypes (for GTCC: P = 0.000, OR = 0.09, 95%CI = 0.05–0.18; for TTCC: P = 0.000, OR = 0.05, 95%CI = 0.01–0.23; for GGCG: P = 0.000, OR = 0.11, 95%CI = 0.06–0.21; for GTCG: P = 0.011, OR = 0.27, 95%CI = 0.10–0.74; for GGGG: P = 0.001, OR = 0.03, 95%CI = 0.00–0.21; for GTCG: P = 0.008, OR = 0.06, 95%CI = 0.01–0.48). Here, PRM1 is linked to male infertility.