Similarly, for rs2301365 in PRM1 and rs1646022 in PRM2, there was a significant protective effect for male infertility in several combined genotypes (for AACC: P = 0.009, OR = 0.13, 95%CI = 0.03–0.60; for ACCC: P = 0.000, OR = 0.12, 95%CI = 0.06–0.23; for CCCG: P = 0.000, OR = 0.27, 95%CI = 0.17–0.44; for CCGG: P = 0.001, OR = 0.03, 95%CI = 0.00–0.22). This evidence concerns the gene PRM2 and male infertility.