High expression level of TBL1XR1 was positively associated with tumor size (OR =2.56; 95 % CI, 1.51–4.35), depth of tumor (OR =2.56; 95 % CI, 1.51–4.35), lymph node metastasis (OR =3.07; 95 % CI, 1.66–5.67) and TNM stage (OR =8.48; 95 % CI, 2.25–31.97). This evidence concerns the gene TBL1XR1 and neoplasm.