The methylation rate of the P16 and APC genes was notably higher in NSCLC than in SCLC (OR = 8.36, 95% CI = 2.37 - 29.51, P = 0.001 and OR = 3.60, 95% CI = 1.54 - 8.39, P = 0.003, respectively). The gene discussed is APC; the disease is non-small cell lung carcinoma.