SHOX2 and lung cancer: Interestingly, the combined sensitivity, specificity, and AUC values of the SHOX2 methylation were 0.75, 0.94, and 0.94, respectively, which were very good (sensitivity = 0.75 > 0.5, specificity = 0.94 > 0.9, and AUC = 0.94 > 0.9), indicating that detection of the SHOX2 methylation could be a specific noninvasive biomarker for lung cancer diagnosis using bronchial aspirates.