The methylation of DAPK1, IGF2, NEUROG1 and WIF1 was associated with CRC risk in both the younger (<60 years) and older groups (≥60 years) (Supplementary Table 3), whereas the associations between the methylation of MGMT and MINT31 and CRC risk were significant only in the younger participants. Here, WIF1 is linked to colorectal carcinoma.