IGF2 and obesity due to melanocortin 4 receptor deficiency: For individual gene-specific methylation, the methylation of DAPK1, IGF2, NEUROG1 and WIF1 was associated with CRC risk in both of the normal weight or underweight group (<24) and the overweight or obese group (≥24) (Supplementary Table 4), whereas the associations between the methylation of CDH1, MGMT and MINT31 and CRC risk were significant only in the overweight or obesity participants.