For individual gene-specific methylation, the methylation of DAPK1, IGF2, NEUROG1 and WIF1 was associated with CRC risk in both of the normal weight or underweight group (<24) and the overweight or obese group (≥24) (Supplementary Table 4), whereas the associations between the methylation of CDH1, MGMT and MINT31 and CRC risk were significant only in the overweight or obesity participants. Here, NEUROG1 is linked to obesity due to melanocortin 4 receptor deficiency.