Univariate analysis showed that RAB27B, ALT, AST, TBil, ALB, ALP, GGT, NLR, AFP, tumor number ≥ 3, tumor size ≥ 5 cm, HBV DNA ≥ 500 IU/ml, Child-Pugh score, hepatic encephalopathy, ascites, lymph node metastasis, BCLC stages and portal vein involvement were associated with decreased overall survival in patients with HCC (p < 0.05, Table 1). This evidence concerns the gene ALB and neoplasm.