MKI67 and neoplasm: Immunohistochemical staining of the tumor tissues demonstrated a marked decrease in staining for Ki-67 in cells treated with a combination of BNTX and TRAIL, and a terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay also showed that the combination of BNTX and TRAIL statistically increased cell death compared with the control group or mice treated with TRAIL alone.