CD47 and cancer: Suggested mechanisms include that the anti-CD47 antibodies: i) induce phosphatidylserine exposure and cell death in the cancer cells by activating CD47 signalling [14, 15], ii) block the ‘don’t-eat-me’ function of CD47, enabling phagocytosis [11], iii) enable greater access of antibodies to cancer cells [16], or iv) induction of antibody-dependent cell-mediated cytotoxicity (ADCC) [17].