Specific recent examples of this: naproxen clinically reduced IL-6 in IL-6-overproducing pheochromocytoma [167], in sera of patient with osteoarthritis [168], in subchondral osteoartrthritis osteoblasts [169], and in osteoarthritis patient synovial cells ex vivo [170]. Here, IL6 is linked to pheochromocytoma.