However, the majority of p53 mutations in cancer do not appear to conform to the TCW DNA motif targeted by A3B, we investigated whether A3B expression is regulated by p53 (ref. (59)), although as has been pointed out, p53 mutations detected in tumours will not simply reflect the exonic nucleotide sequence, but the selection imparted by the resultant amino acid change (60). The gene discussed is TP53; the disease is neoplasm.