SHFM can also be found as an isolated feature or associated to other syndromes that are not related to p63, such as ectodermal dysplasia, ectrodactilia and macular dystrophy (EEM) (OMIM 225280) and acro-cardio-facial syndrome (ACFS) (OMIM 600460). Here, TP63 is linked to Acro-cardio-facial syndrome.