SHFM can also be found as an isolated feature or associated to other syndromes that are not related to p63, such as ectodermal dysplasia, ectrodactilia and macular dystrophy (EEM) (OMIM 225280) and acro-cardio-facial syndrome (ACFS) (OMIM 600460). The gene discussed is TP63; the disease is ectodermal dysplasia syndrome.