First, acromegaly is not always accompanied by a typical phenotype as highlighted by some authors: “acromegaly is a clinical syndrome that may not manifest with clear diagnostic features” (1); “some patients with acromegaly have mild or absent clinical features” (2); “we suggest the measurement of IGF-1 in patients without the typical manifestations of acromegaly, but who have several associated conditions” (3), and “the diagnosis does not require the presence of typical phenotypic features” (4). The gene discussed is IGF1; the disease is acromegaly.