On the other hand, the cell apoptotic percentage accounted for 9.1% (3.9+5.2%) in HIF-1α overexpression group and 16.7% (8.2+8.5%) in HIF-1α knockdown group, suggesting that HIF-1α overexpression abrogated propranolol-induced hemangioma cells apoptosis. Here, HIF1A is linked to hemangioma.