COL18A1 and mitral valve disorder: Particularly, an increased LAVi withoutconcomitant mitral valve disease reflects a chronic remodeling process typical forHFpEF.25 Consistently, wefound that elevated Endostatin levels were associated with elevated NT-proBNPlevels, a well-recognized prognostic marker and indicator of elevated ventricularfilling pressures among patients, independent from LVEF.26