The profound loss of ALL mitochondrial dynamic proteins examined (DRP1, MFF, OPA1, OMA1, YME1L, MFN1, MFN2) after CS/Tx may indicate altered mitochondrial biogenesis (synthesis), but the data showing no change in MnSOD or Core 2 indicate that this is unlikely. The gene discussed is YME1L1; the disease is acute lymphoblastic leukemia.