The profound loss of ALL mitochondrial dynamic proteins examined (DRP1, MFF, OPA1, OMA1, YME1L, MFN1, MFN2) after CS/Tx may indicate altered mitochondrial biogenesis (synthesis), but the data showing no change in MnSOD or Core 2 indicate that this is unlikely. This evidence concerns the gene SOD2 and acute lymphoblastic leukemia.