Recent data indicated that P37 promoted tumor progression through its interaction with ANXA2 in host cells, while P37 antibodies, a polypeptide A2PP (a 30 amino acids polypeptide within the N-terminal of ANXA2), and anti-mycoplasma reagent like MYCO I, were able to block this interaction[16]. The gene discussed is ANXA2; the disease is neoplasm.