The real existence and the importance of this regulatory mechanism is further supported by recent studies demonstrating that an increase of Plakoglobin nuclear translocation is associated with diseases such as arrhythmogenic right ventricular cardiomyopathy or head neck cancer and leads to a suppression of the β-catenin mediated TCF/LEF transcriptional activity [79, 80]. This evidence concerns the gene HNF4A and Arrhythmogenic right ventricular dysplasia.