It is also important to note that, unlike other novel cytotoxic enzymes of human origin (e.g., granzyme B and angiogenin) that are mostly limited as a result of upregulation of their endogenous inhibitors by target cells, DAPk1 and DAPk2 with its autoregulatory CaM domain removed theoretically are able to bypass tumor drug escape or resistance mechanisms. The gene discussed is DAPK2; the disease is neoplasm.