This barrier crossing is attributed to the expression of P-selectin on activated tumor endothelial cells (Barthel et al., 2007; Läubli and Borsig, 2010; Shamay et al., 2016a), as binding of the dendritic conjugate to the endothelium facilitates its extravasation via blood vessels to the target site (Ofek et al., 2016). Here, SELP is linked to neoplasm.