THBS1 and ovarian cancer: TSP-1 PM used here is a second generation peptide of ABT-510, which was shown to enhance the efficacy of both PTX and of cisplatin in an orthotopic syngeneic model of ovarian cancer through normalization of tumor vasculature, as documented by increased pericytes coating tumor vessels, leading to increased concentration of these agents in the tumor (Campbell et al., 2010).