Conversely, expression levels of committed osteogenic genes such as collagen type 1α1 (COL1A1) 32 and the RUNX2 coactivator c‐MAF 17, 33 were decreased in C3H MSCs cultured in OM with exogenous H2O2 treatment (Fig. 2A). The gene discussed is RUNX2; the disease is ocular melanoma.