Infection results in the percentage of CD4+CD25+Foxp3+ cells falling from 96.7% of all CD4+CD25+ cells in the CSF of EAE mice to 93.8%, and from 71.1% of all CD4+CD25hi cells in the CSF of EAE mice to 61.4% (Fig. 6a, b). The gene discussed is CD4; the disease is infection.