Infection results in the percentage of CD8+CD25+Foxp3+ cells falling from 39.5% of all CD8+CD25+ cells in the CSF of EAE mice to 30.1% and from 95.7% of all CD8+CD25hi cells in the CSF of EAE mice to 82.5% (Fig. 6a, b). The gene discussed is CD8A; the disease is infection.