As use of SBRT combined with erlotinib showed remarkable outcomes in oligoprogressive metastatic NSCLC (50), a pilot study from Memorial Sloan Kettering Cancer Center (NCT02450591) is now evaluating outcomes when SBRT or surgery is added to erlotinib for newly diagnosed oligometastatic lung adenocarcinoma harboring a sensitizing EGFR mutation with the goal to evaluate feasibility and PFS. This evidence concerns the gene EGFR and lung adenocarcinoma.