MTOR and neoplasm: Although pharmacological inhibition of mTORC1 by rapamycin promoted autophagy in the model of yeasts grown in the presence of nutrients as well as in various tumor cell lines,23 different effects of mTOR inhibitors on the expression of differentiation markers have been reported in leukemia cell lines.24–27 As shown in Figure 2a, the presence of 20 nM rapamycin prevented an increase in the expression of CD64 and CD11b induced by AICAR.