Contrary to the causative role of impaired mitophagy in PINK1/Parkin-related PD, the observation in MC on the ability of Nix to independently mediate mitophagy and thereby maintain normal mitochondrial function suggests that increased levels of Nix may compensate for the loss of PINK1/Parkin-mediated mitophagy in PD. Here, PRKN is linked to Parkinson disease.