Overweight mothers are recommended to gain less weight during pregnancy, so gestational weight gain in GDM mothers was smaller compared to controls (average 9.3 ± 9.6 kg in GDM vs. 15.9 ± 9.7 kg in controls, p = 0.05) and as a consequence HDL-LpPLA2 activity was inversely correlated with maternal gestational weight gain (Fig. 6e, r = −0.35, p = 0.05). The gene discussed is PLA2G7; the disease is gestational diabetes.