In reference to complement and coagulation cascades the pathogenesis of idiopathic interstitial pneumonia (IIP) shows that among other potentially relevant differentially expressed transcripts are complement components (B factor, H factor-1, and complement factor H–related 3), members of the coagulation cascade (tissue factor pathway inhibitors 1 and 2)55. Here, CFHR3 is linked to idiopathic interstitial pneumonia.