TSC1 and epilepsy: Together with the remarkable similarity of Depdc5 and TSC null mouse phenotypes our findings support the hypothesis that mTORC1 deregulation is likely to underpin DEPDC5 related epilepsy and raises the possibility that mTORC1 inhibition may be a viable therapeutic option in patients with DEPDC5 mutations as is being investigated for TSC patients47 (reviewed in48).