This difference was observed in 5′RACE assays using GSP1 (Fig. 5A; p = 0.008 in the AD brain and p = 0.085 in the PSP brain) and GSP4 (Fig. 5B; p = 0.0006 in the AD brain and p = 0.005 in the PSP brain). The gene discussed is RAN; the disease is Alzheimer disease.