HUGL-1 appears completely released from the membrane (Fig. 1D,G), YAP shows cytoplasmic and nuclear enrichment (Fig. 1E,H), c-MYC is overexpressed (Fig. 1F,I) and a number of stromal cells at the tumour-stroma interface are positive to Cas3 (Fig. 1F,I, arrowheads in I i.s.). The gene discussed is YAP1; the disease is neoplasm.