Similar phenotypes were observed in colon-derived liver metastasis (Fig. 1J–O), where HUGL-1 is delocalised (Fig. 1J,M), YAP is abundant in the cytoplasm and stains some cell nuclei (Fig. 1K,N) and c-MYC-positive tumour cells (Fig. 1L,O) enclose Cas3-positive stromal cells (Fig. 1L,O arrowheads i.s.). This evidence concerns the gene EFS and neoplasm.