Figure 1A–C shows an in situ colon carcinoma where HUGL-1 is partly dispersed throughout the cytoplasm (the arrow in Fig. 1A indicates an example of membrane retention), YAP is mildly expressed all across the cellular volume (Fig. 1B), the tumour parenchyma expresses low levels of c-MYC (Fig. 1C) and a number of epithelial (arrows indicate some -hereafter i.s.-) and stromal cells (arrowheads i.s.)are positive to the Cas3 antibody. The gene discussed is YAP1; the disease is colon carcinoma.