Figure 3A–F shows two cases of invasive lung cancer where HUGL-1 appears completely delocalised/lost (Fig. 3A,D), YAP and c-MYC are aberrantly expressed in the nuclei (Fig. 3B,C) or in the whole cellular volume (Fig. 3E,F) and, again, a number of Cas3-positive stromal cells are dispersed amid tumour cells (arrowheads i.s. in Fig. 3C,F). Here, YAP1 is linked to lung cancer.