This change resulted in a higher degree of insulin resistance (p = 0.002, two-way ANOVA) and lower insulin sensitivity (p = 0.042, two-way ANOVA), measured as the HOMA-IR and R-QUICKI indexes, respectively, in both STD-GSPE and CAF-GSPE animals than in their counterparts (Fig. 3E and F). The gene discussed is INS; the disease is Insulin resistance.