This phenotype was apparent in the following observations: 1) decreased gene expression of adiponectin receptors (AdipoR1 and AdipoR2 in IWAT and AdipoR2 in soleus muscle); 2) hyperinsulinemia, decreased insulin sensitivity and increased insulin resistance; and 3) decreased levels of the downstream post-receptor target of adiponectin, p-AMPK, in the soleus muscle. Here, ADIPOR2 is linked to hyperinsulinism.