It has been well accepted that TAMs in cancer tissues bear complicated characteristics rather than simply M2 or M1, and, it is noteworthy that TAMs exhibit non classical M2/M1 phenotypes2, 3 To answer the question whether caspase-1 mediated PPARγ cleavage plays an exclusive role in TAM differentiation, we investigated whether PPARγ was cleaved in macrophages exposed to stimulus of either classical activation (M1) or alternative activation (M2). This evidence concerns the gene PPARG and cancer.