Similar to the results of the coculture analysis, PPARγ cleavage was observed in primary TAMs isolated from 2 separate tumor models: a transgenic mouse model exhibiting spontaneous breast tumors-MMTV-PyMT mice model (Fig. 1d) and the orthotopic-grafted breast cancer mouse model (Fig. 1e) generated by injecting 4T1 cells into female 9-week-old BALB/c mice. This evidence concerns the gene PPARG and breast cancer.