We also identified several novel recurrently mutated genes in insulinomas, including H3 histone family 3A (H3F3A; two tumors), lysine-specific demethylase 6A (KDM6A; two tumors), Filamin C gamma (FLNC; two tumors), ATR serine/threonine kinase (ATR; two tumors), and Rho GTPase-activating protein 35 (ARHGAP35; two tumors). The gene discussed is KDM6A; the disease is pancreatic insulinoma.