In addition, frequent loss-of-copy/cnLOH of CDKN1C, which resides on chromosome 11p15 and encodes the cell cycle inhibitor p57KIP2, was also observed in 9 of 26 insulinomas (Fig. 1b), as reported previously in pediatric insulinomas18. The gene discussed is CDKN1C; the disease is pancreatic insulinoma.