Pursuing the ‘‘epigenetic modifier’’ gene ontology signature from the earlier mutational analysis, we also surveyed CNVs harboring other epigenetic modifiers in addition to MEN1. Among this class, the EZH2 locus on chromosome 7 (7q36.1) displayed a gain of copy CNV in 10 of 26 insulinomas (Fig. 1b). This evidence concerns the gene EZH2 and pancreatic insulinoma.