Insulinomas also display CNV loss, copy-neutral LOH in the 11p15 region overlapping with key regulatory elements (e.g., transcriptional start sites, enhancers, CTCF-binding sites, ICRs, splice sites) of important transcripts in this region including INS, INS-IGF2, IGF2, KCNQ1, KCNQ1OT, H19, and CDKN1C. This is corroborated by marked overexpression of H19 and KCNQ1 and underexpression of CDKN1C in the large majority of insulinomas, as described in more detail below. This evidence concerns the gene CTCF and pancreatic insulinoma.