We selected CDKN1C as a target because it is the only cell cycle inhibitor in the bisque4 MMP list (Fig. 5d), because it is reproducibly reduced in insulinomas (Fig. 5e, f), because its loss is associated with beta cell proliferation in FoCHI and BWS31–34, because CDKN1C is expressed only in beta cells in human islets23–25, 32, and, because silencing CDKN1C leads to induction of human beta cell proliferation in our hands (Fig. 5g) and others39. The gene discussed is CDKN1C; the disease is pancreatic insulinoma.