Interestingly, the seven recurrently mutated genes identified in 10 of the 26 insulinomas (five being epigenetic regulators: YY1, MEN1, H3F3A, KDM6A, ATR) are significantly enriched for epigenetic regulators as defined by the curated database, EpiFactors13 (fold enrichment = 16.7, p = 2.8 × 10−6; Fisher’s exact test). This evidence concerns the gene ATR and pancreatic insulinoma.