Chromosome 11 errors, suggested by recurrent loss of this region and the unique ASE profile, as well as imprinting errors directly confirmed by deep CpG methylome sequencing, with congruent increases in H19, KCNQ1, and recurrent loss of CDKN1C (Fig. 4), also likely contribute to a large subset of insulinomas. Here, H19 is linked to pancreatic insulinoma.