MEN1 and pancreatic insulinoma: Importantly, the average of 3.5 driver mutations and multiple additional CNV gains and losses that characterize insulinomas (Figs. 1 and 6) is congruent with the observation that MEN1-associated human insulinomas occur only after decades5–7, and that loss of both men1 alleles in mice nonetheless requires months of latency before insulinomas appear48.