INS and pancreatic insulinoma: Insulinomas also display CNV loss, copy-neutral LOH in the 11p15 region overlapping with key regulatory elements (e.g., transcriptional start sites, enhancers, CTCF-binding sites, ICRs, splice sites) of important transcripts in this region including INS, INS-IGF2, IGF2, KCNQ1, KCNQ1OT, H19, and CDKN1C. This is corroborated by marked overexpression of H19 and KCNQ1 and underexpression of CDKN1C in the large majority of insulinomas, as described in more detail below.