To determine if a direct link exists between trithorax members and cell cycle machinery in human beta cells, we selected the H3K27me3 demethylase, KDM6A, for further study, since it is a canonical trithorax member, since it is one of the rare recurrently mutated genes in insulinoma (Fig. 1), since it’s expression is reduced in insulinomas, (Supplementary Data 8) and since its biology has not previously been explored in human beta cells. Here, KDM6A is linked to pancreatic insulinoma.