The observations that CDKN1C (rather than CDKN2A) was the CDK inhibitor best co-correlated with bisque4, and that EZH2 can transcriptionally repress CDKN1C43 suggest that combined EZH2 and CDKN1C loss/repression may be critical to enable proliferation in insulinoma cells. The gene discussed is CDKN1C; the disease is pancreatic insulinoma.