For example, exon-level analysis identified the major histocompatibility II transcriptional regulator, CIITA (Simes Test FDR = 4.2 × 10−27), which was also upregulated at the DEG level in insulinomas, as being among the top 10 most differentially spliced genes (DSGs) in insulinomas (Supplementary Data 10). Here, CIITA is linked to pancreatic insulinoma.