Pretreatment with anti-BgA MAb (Fig. 4D-1) or S. sieboldiana lectin (Fig. 4D-2) reduced the binding of His-Sia to PCM, while a mouse IgM control and mannose-binding lectin from Canavalia ensiformis (concanavalin A [ConA]) had little or no effect on the SiaBb2 signal. This evidence concerns the gene CD40LG and paracoccidioidomycosis.