Thus, in this study, we demonstrate that the mechanism underlying rL-RVG-induced anti-cancer activity in A549 lung cancer cells could be that rL-RVG enhances the apoptosis and inhibits the migration of A549 cells via regulating α7 nAChRs; we also present relationships between α7 nAChR expression and the clinical features of this condition. The gene discussed is CHRNA7; the disease is lung cancer.