α7 nAChRs may activate β2-adrenergic dependent SRC, epidermal growth factor receptor, AKT, Survivin, NF-κB and the epithelial-mesenchymal transition to promote the proliferation of NSCLC cells through the RAS system [29–33] and promote the proliferation, angiogenesis, invasion and metastasis of lung cancer cells [22, 34–36]. Here, NFKB1 is linked to lung cancer.