CASP8 and lung cancer: Consistent with these discoveries, our previous study showed that rL-RVG was able to suppress lung cancer cell growth and promote lung cancer cell apoptosis to a greater extent than the wild-type NDV strain, as well as dramatically increase the levels of the apoptosis-related proteins caspase-3, caspase-8, caspase-9 and Bax in A549 cells [7].