They divide rapidly once activated and secrete cytokines that regulate or involve in the active immune responses.15 The CD8+ activation requires help from CD4+ T cells, which directly stimulate cytotoxic T-lymphocyte responses.46 Shan et al47 evaluated the expression of TIM-3 in CD4+ T cells in patients with active ITP, patients with ITP in remission, and in healthy participants. The gene discussed is CD4; the disease is autoimmune thrombocytopenic purpura.