While elucidating the distribution of FGFR1 in the cortex and hippocampus of patients with Alzheimer’s disease, immunoreactivity of the FGFR1 (that binds FGF1/2) was augmented in responsive astrocytes, neighboring senile plaques in patients with Alzheimer’s disease when compared to age-matched controls [245]. Here, FGFR1 is linked to early-onset autosomal dominant Alzheimer disease.