VEGFA and hypertensive disorder: It is important to note that anti-VEGF/VEGFR therapies, particularly against cancer, have been associated with severe side-effects such as hypertension, gastro-intestinal toxicity, hypothyroidism, proteinuria, coagulation disorders, headache, dyspnea, fatigue, anorexia, stomatitis, diarrhea, neurotoxicity and thrombotic microangiopathy [43,44,45].