Furthermore, according to Murakami et al.’s reports, ZER can significantly induce in a time and concentration-dependent manner, the expressions of TNF-α, IL-1α, IL-1β and IL-6 in human colon adenocarcinoma (Caco-2, Colo320DM, and HT-29) cell lines [21]. The gene discussed is TNF; the disease is colon adenocarcinoma.