Also, the EMT-inducing transcriptional repressor ZEB1 has been shown to directly interact with and activate the Hippo pathway effector YAP [73], and the E3 ubiquitin-protein ligase Itchy homolog (ITCH) has been shown to enhance EMT in breast cancer by negatively regulating LATS1, and therefore increasing YAP activity [74]. Here, ITCH is linked to breast cancer.