Numerous studies have indicated that the failure of molecular mechanisms under apoptosis in chemoresistant and/or advanced ovarian cancer cells include the down-regulation of pro-apoptotic proteins Puma, Bax, and Bad, and the up-regulation of the anti-apoptotic protein Bcl-2 family including, Bcl-2 and Bcl-xL. This evidence concerns the gene BCL2 and ovarian cancer.