In the PREDIMED (PREvención con DIeta MEDiterránea), study, the Mediterranean diet (MeDiet) supplemented with EVOO (1 liter/week), compared to the control group (low-fat diet), was able to significantly reduce proinflammatory cytokines (IL6) (P-selectin, sVCAM and sICAM) in subjects at high cardiovascular risk (type 2 diabetes mellitus alone or ≥3 other risk factors: hypertension, HDL ≤ 40 mg/dl, LDL ≥ 160 mg/dl, overweight or obesity, smoking, family history of premature CAD), at short- (3 months) and long-term (1 year) follow-up [9,142]. Here, IL6 is linked to type 2 diabetes mellitus.