This study also demonstrated that ectopic expression of miR-34a causes the down regulation of N-cadherin and Snail, and induction of E-cadherin in LNCaP and C4-2B cell lines, overall suggesting that miR-34a-LEF1 regulation plays an important role in the metastatic progression of PCa [128]. The gene discussed is CDH2; the disease is posterior cortical atrophy.