Analysis of DNA extracted from the PC and RCC tumors from case 10 with the germline mutation in the MAX gene (c.97C>T p. Arg33*) revealed loss of heterozygosity (Supplemental Fig. 4), with higher reads in the mutant allele identified in the PC [reads wild-type/mutant: 77/151 (depth 228) and RCC (reads: 60/179, depth 239) compared with the germline (157/157, depth 314) [germline.v’s.PC P = 0.0002; germline.v’s.RCC P < 0.0001 (Fisher’s exact test)]. The gene discussed is MAX; the disease is renal cell carcinoma.