Specific aims were (1) to assess the strength of the association of 5-year changes in PA with concomitant changes in the levels of FPG, 2hPG, HbA1c, insulin sensitivity, and β-cell function in prediabetes defined by the glucose vs HbA1c criteria, and (2) to examine potential heterogeneity in the association of baseline PA with reversion to normoglycemia in prediabetic subgroups and across age, sex, and obesity degree. This evidence concerns the gene INS and prediabetes syndrome.