IFNG and myocarditis: In addition, the polarization of adaptive immunity is also affected by TLR3, as it has been shown that TLR3-deficient mice on the B6.129 background develop a IL-4-producing Th2 response profile during CVB3 myocarditis instead of the IFN-γ-producing Th1 phenotype observed in resistant B6.129 mice [28].