Other studies also suggested the importance of alternative splicing of MdmX as the ratio between the short MdmX-S isoform and the full-length MdmX transcript strongly correlated with MdmX protein levels and could serve as a prognostic marker in osteosarcoma, breast carcinoma and CLL [11–13]. This evidence concerns the gene MDM4 and B-cell chronic lymphocytic leukemia.